CRP Antiserum

  Hyperimmune anti-CRP

Hyperimmune anti-CRP is manufactured exclusively for Technicon at IMVS-Institute of
 Medical and Veterinary Science, Adelaide, Australia as shown on a typical product data sheet below.
 Here are some photos taken around the IMVS farm featuring some typical views.
The Manufacture of Anti-CRP

 The animal (goat) is immunized with CRP antigen (recombinant human C-reactive
 protein). Only animals which have reached the standard titer level by the known
 titration method, are bled in plasma. Then, after the defibrination and dilapidation
 processes, the antiserum is pooled and membrane filtered to organize a production
 lot, and then sent to the QC to measure total protein, protein electrophoresis, total
 immunoglobulin, specific IgG to CRP etc.

 All the manufacturing processes for the hyperimmune anti-CRP production are
 conducted at IMVS (Institute of Medical and Veterinary Science, Adelaide, S. Australia
 - with the ISO 9002 certification ). Also, this product is manufactured exclusively for
 supply to Technicon International, Inc. Tokyo, Japan.

 Veterinary Services at IMVS:
 The veterinary services provide the following functions.

 -Provide animal research facilities and animal care staff
 resources from IMVS, RAH, University of South Australia.

 -Contact biomedical research.

 -Produce and market a large range of value added biological products.

 -Provide undergraduate teaching to Adelaide Physiology and
 Animal Sciences (Agriculture) students, and design and
 deliver TAFE Associate Diploma courses to animal
 technicians of whom the IMVS is a major employer.

 Link: http//

 CRP Assay & CRP Diagnosis:
 CRP is used as an in vitro diagnostic marker to aid in the evaluation of the amount of
 injury to human body tissue CRP (C-reactive protein) is plasma protein, mainly
 produced in the liver, whose concentration increases dramatically during the acute phase
 inflammatory response. Inflammation and other pathological processes such as coronary
 artery disease, stroke, heart attack, and others may increase CRP levels to be elevated 
 as much as 2000 fold. CRP is also useful as a prognostic indicator for the risk of 
 cardiovascular disease in general. CRP levels are very helpful in determining, not 
 only the degree of damage from a cardiac episode as related to the post-CRP 
 concentration but to aid in assessing the risk of future serious cardiac co

Product Data Sheet

Product: Goat Serum (Defibrinated citrated plasma) Hyperimmune anti-CRP
Product Code: GTHC
Batch No.: 2421
Date of Manufacture: 27th March 2002
Immunogen Recombinant human C-reactive protein (CRP)
[E.coli pentraxin, whole molecule NW 115,000]
Host Goat
Appearance Clear pale straw color liquid
Physical form Whole serum, separated from clotted blood
Storage Frozen - ‚Q0Ž
Sterility 3.0 ƒΚ membrance filter to clarify serum.
Not sterility tested
Bacterial culture
Total protein 65 g/L Biuret method
Protein electrophoresis Normal electrophoresis pattern, apart from
 an increased immunoglobulin fraction
Capillary Electrophoresis
Total immunoglobulin 14.3 g/L (22% of total protein) Calculated
Specific IgG (to CRP)  2.7 mg/ml (g/L) Solid Phase Affinity
immuno-absorption Assay

Contact: Technicon International, Inc. (Tokyo, Japan)