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CRP Antiserum
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Hyperimmune anti-CRP
Hyperimmune anti-CRP is manufactured exclusively for Technicon at IMVS-Institute of
Medical and Veterinary Science, Adelaide, Australia as shown on a typical product data sheet below.
Here are some photos taken around the IMVS farm featuring some typical views. |
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The Manufacture of Anti-CRP
The animal (goat) is immunized with CRP antigen (recombinant human C-reactive
protein). Only animals which have reached the standard titer level by the known
titration method, are bled in plasma. Then, after the defibrination and dilapidation
processes, the antiserum is pooled and membrane filtered to organize a production
lot, and then sent to the QC to measure total protein, protein electrophoresis, total
immunoglobulin, specific IgG to CRP etc.
All the manufacturing processes for the hyperimmune anti-CRP production are
conducted at IMVS (Institute of Medical and Veterinary Science, Adelaide, S. Australia
- with the ISO 9002 certification ). Also, this product is manufactured exclusively for
supply to Technicon International, Inc. Tokyo, Japan.
Veterinary Services at IMVS:
The veterinary services provide the following functions.
-Provide animal research facilities and animal care staff
resources from IMVS, RAH, University of South Australia.
-Contact biomedical research.
-Produce and market a large range of value added biological products.
-Provide undergraduate teaching to Adelaide Physiology and
Animal Sciences (Agriculture) students, and design and
deliver TAFE Associate Diploma courses to animal
technicians of whom the IMVS is a major employer.
Link: http//www.imvs.sa.gov.au/
CRP Assay & CRP Diagnosis:
CRP is used as an in vitro diagnostic marker to aid in the evaluation of the amount of
injury to human body tissue CRP (C-reactive protein) is plasma protein, mainly
produced in the liver, whose concentration increases dramatically during the acute phase
inflammatory response. Inflammation and other pathological processes such as coronary
artery disease, stroke, heart attack, and others may increase CRP levels to be elevated
as much as 2000 fold. CRP is also useful as a prognostic indicator for the risk of
cardiovascular disease in general. CRP levels are very helpful in determining, not
only the degree of damage from a cardiac episode as related to the post-CRP
concentration but to aid in assessing the risk of future serious cardiac co
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Product Data Sheet
Product: Goat Serum (Defibrinated citrated plasma) Hyperimmune anti-CRP
Product Code: GTHC
Batch No.: 2421
Date of Manufacture: 27th March 2002
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| Immunogen |
Recombinant human C-reactive protein (CRP)
[E.coli pentraxin, whole molecule NW 115,000] |
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| Host |
Goat |
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| Appearance |
Clear pale straw color liquid |
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| Physical form |
Whole serum, separated from clotted blood |
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| Storage |
Frozen - Q0 |
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| Sterility |
3.0 Κ membrance filter to clarify serum.
Not sterility tested |
Bacterial culture |
| Total protein |
65 g/L |
Biuret method |
| Protein electrophoresis |
Normal electrophoresis pattern, apart from
an increased immunoglobulin fraction |
Capillary Electrophoresis |
| Total immunoglobulin |
14.3 g/L (22% of total protein) |
Calculated |
| Specific IgG (to CRP) |
2.7 mg/ml (g/L) |
Solid Phase Affinity
immuno-absorption Assay |
Contact: Technicon International, Inc. (Tokyo, Japan)
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